LIPH

Across TCGA cell cohorts, LIPH mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LIPH-associated genes across cancer lineages are KRTAP10-2, C16orf96, and SHCBP1L. Each is linked with LIPH in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPH-to-partner and partner-to-LIPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-2 grouped by LIPH-low versus LIPH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPH→partner) and Y-score (partner→LIPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
SKIN	SHCBP1L →	+0.044	+3.930	<.001	.003	3	1
SKIN	APELA →	+0.063	+4.877	<.001	.001	3	1
SKIN	IFNL4 →	+0.032	+4.882	.008	<.001	3	1
SKIN	TP53TG3E →	+0.575	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRTAP10-2 by LIPH expression — LARGE_INTESTINE

Explore this box plot interactively →