LIPE

Across TCGA cell cohorts, LIPE mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIPE-associated genes across cancer lineages are KRTAP4-4, KLRC3, and CA5A. Each is linked with LIPE in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPE-to-partner and partner-to-LIPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-4 grouped by LIPE-low versus LIPE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPE→partner) and Y-score (partner→LIPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP4-4 →	+0.008	+3.762	<.001	.007	3	2
BLOOD_Myeloma	KLRC3 →	+0.035	+3.906	.001	.009	3	1
URINARY_TRACT	CA5A →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	KRTAP4-12 →	+0.230	+4.217	.001	.005	3	1
CNS	IL3 →	+0.038	+4.981	<.001	.008	3	1
LARGE_INTESTINE	KCNK17 →	+0.094	+3.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

KRTAP4-4 by LIPE expression — BLOOD_Leukemia

Explore this box plot interactively →