LIPE

Across TCGA pan-cancer cohorts, LIPE RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LIPE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LIPE RNA is repressed in tumor relative to normal tissue. In most cancer types LIPE is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and BRCA are the cancer types where LIPE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIPE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−1.215	<.001	11	view →
COAD	All	II,III,IV	+0.621	<.001	10	view →
BRCA	All	II,III,IV	−3.880	<.001	8	view →
KICH	Female	All	−0.958	<.001	8	view →
LIHC	All	All	+0.604	<.001	7	view →
KIRP	Male	III,IV	−1.198	<.001	6	view →
BLCA	Male	III,IV	−0.924	.003	4	view →
KIRC	All	II,III,IV	−0.371	.003	4	view →
UCEC	All	All	−0.826	<.001	2	view →
PRAD	All	All	−0.722	<.001	2	view →
CHOL	All	All	+0.721	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LIPE–HNSC

Open the HNSC breakdown →