LIPE

Across TCGA cell cohorts, LIPE mutation is significantly associated with the mutation status of many other genes, with 3,366 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIPE-associated genes across cancer lineages are FOXO3, WDR81, and ATG2A. Each is linked with LIPE in more than 3 cancer types. Because this analysis shows association rather than direction, both LIPE-to-partner and partner-to-LIPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3 grouped by LIPE-low versus LIPE-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPE→partner) and Y-score (partner→LIPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FOXO3 →	+4.584	+3.942	.002	.002	1	4
LARGE_INTESTINE	WDR81 →	+2.152	+2.787	.005	.005	1	4
PANCREAS	ATG2A →	+5.115	+5.115	.005	.005	1	3
PANCREAS	NWD1 →	+5.115	+5.115	.005	.005	1	3
PANCREAS	PCDH18 →	+5.115	+5.115	.005	.005	1	3
BLOOD_Myeloma	DYSF →	+3.285	+3.906	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,366 associations by consensus.

FOXO3 by LIPE expression — STOMACH

Explore this box plot interactively →