LIPC

Across TCGA patient cohorts, LIPC mutation is significantly associated with the RNA expression of many other genes, with 3,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPC-associated genes across cancer lineages are MIR4802, RNA5SP452, and MAPK6P6. Each is linked with LIPC in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPC-to-partner and partner-to-LIPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4802 grouped by LIPC-low versus LIPC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPC→partner) and Y-score (partner→LIPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR4802 →	+0.335	+3.735	.001	.005	3	2
READ	RNA5SP452 →	+0.689	+4.724	<.001	.003	3	2
READ	MAPK6P6 →	+0.108	+4.280	<.001	.007	3	2
READ	KRTAP9-4 →	+0.185	+4.421	<.001	.009	3	2
READ	NUDT19P5 →	+0.143	+4.445	.002	.005	3	2
LUAD	SOCS5P5 →	+0.088	+3.659	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,385 associations by consensus.

MIR4802 by LIPC expression — BLCA

Explore this box plot interactively →