LIPC

Across TCGA pan-cancer cohorts, LIPC RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LIPC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LIPC RNA is repressed in tumor relative to normal tissue. In most cancer types LIPC is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where LIPC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIPC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−3.210	<.001	11	view →
COAD	Female	III,IV	−1.367	<.001	11	view →
THCA	All	IV	−0.879	<.001	10	view →
STAD	All	II,III,IV	+0.745	.001	7	view →
UCEC	All	All	−0.530	<.001	6	view →
BRCA	Female	II,III,IV	−0.319	<.001	6	view →
READ	All	All	−0.785	<.001	5	view →
CHOL	Male	All	−3.489	<.001	4	view →
LIHC	Female	All	−1.664	<.001	4	view →
KIRP	All	All	+1.002	.013	3	view →
BLCA	Male	IV	+2.430	.018	2	view →
PRAD	All	All	−0.234	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LIPC–KICH

Open the KICH breakdown →