LIPC

Across TCGA pan-cancer cohorts, LIPC RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LIPC data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LIPC RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LIPC expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, OV, and KIRC are the cancer types where LIPC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.624	0.459	<.001	69	view →
OV	OS	Tertile	II,III,IV	0.627	0.728	.017	46	view →
KIRC	DFS	Median	IV	0.625	0.369	<.001	46	view →
LGG	OS	Median	All	0.376	0.518	<.001	44	view →
LAML	DFS	Quartile	All	0.305	0.582	.015	28	view →
SKCM	OS	Tertile	IV	0.922	0.418	.002	27	view →
UVM	DFS	Quartile	All	0.376	0.904	.008	21	view →
THYM	OS	Median	All	1.000	0.660	.006	20	view →
UCEC	OS	Quartile	All	0.794	0.920	<.001	18	view →
LIHC	OS	Quartile	All	0.908	0.748	.005	16	view →
LUAD	DFS	Tertile	III,IV	0.558	0.269	.020	15	view →
TGCT	DFS	Quartile	All	0.550	0.815	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LIPC–HNSC (DFS)

Open the HNSC breakdown →