LIPC

Across TCGA cell cohorts, LIPC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,573 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LIPC-associated GO terms across cancer lineages are Response to hypoxia, Viral gene expression, and Regulation of fibroblast growth factor receptor signaling pathway. Each is linked with LIPC in more than 5 cancer types. Because this analysis shows association rather than direction, both LIPC-to-partner and partner-to-LIPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to hypoxia grouped by LIPC-low versus LIPC-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPC→partner) and Y-score (partner→LIPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Response to hypoxia →	+0.041	+0.413	<.001	.001	3	6
BONE	Viral gene expression →	+0.100	+0.407	<.001	.006	3	6
BONE	Regulation of fibroblast growth factor receptor signaling pathway →	+0.277	+0.470	<.001	.002	3	6
BONE	Protein exit from endoplasmic reticulum →	+0.133	+0.620	<.001	.007	3	6
OESOPHAGUS	Protein localization to plasma membrane →	+0.088	+0.118	<.001	.002	3	5
OVARY	Negative regulation of muscle cell apoptotic process →	+0.067	+1.248	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,573 associations by consensus.

Response to hypoxia by LIPC expression — CNS

Explore this box plot interactively →