LIPC

Across TCGA cell cohorts, LIPC mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible LIPC-associated genes across cancer lineages are ARGFX, CELA3A, and FCRL4. Each is linked with LIPC in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPC-to-partner and partner-to-LIPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by LIPC-low versus LIPC-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPC→partner) and Y-score (partner→LIPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARGFX →	+0.106	+5.087	<.001	.004	3	1
OESOPHAGUS	CELA3A →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	FCRL4 →	+0.013	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	TAS1R2 →	+0.007	+3.604	<.001	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.132	+3.823	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ARGFX by LIPC expression — URINARY_TRACT

Explore this box plot interactively →