LINGO1

Across TCGA patient cohorts, LINGO1 mutation is significantly associated with the RNA expression of many other genes, with 3,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINGO1-associated genes across cancer lineages are MIR5089, RNU6-502P, and CYP4F27P. Each is linked with LINGO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LINGO1-to-partner and partner-to-LINGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5089 grouped by LINGO1-low versus LINGO1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO1→partner) and Y-score (partner→LINGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR5089 →	+0.769	+5.653	<.001	.003	3	4
READ	RNU6-502P →	+0.413	+6.681	<.001	<.001	3	4
UCEC	CYP4F27P →	+0.159	+1.703	.006	<.001	3	4
UCEC	ZNHIT3 →	+0.356	+1.879	.001	<.001	3	3
UCEC	HINT1 →	+0.419	+2.291	<.001	<.001	3	3
UCEC	TYMS →	+0.536	+2.053	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,362 associations by consensus.

MIR5089 by LINGO1 expression — READ

Explore this box plot interactively →