LINGO1

Across TCGA pan-cancer cohorts, LINGO1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LINGO1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINGO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINGO1 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

KIRC, LIHC, and LUAD are the cancer types where LINGO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINGO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.049	<.001	12	view →
LIHC	Female	II,III,IV	+2.054	<.001	9	view →
LUAD	Male	II,III,IV	+1.443	<.001	9	view →
LUSC	All	II,III,IV	+1.399	<.001	7	view →
COAD	Female	All	+0.796	<.001	7	view →
THCA	All	All	+0.649	<.001	7	view →
HNSC	All	All	+0.596	<.001	7	view →
BRCA	All	III,IV	+1.707	<.001	6	view →
BLCA	All	All	+1.007	.005	6	view →
STAD	Male	All	+1.161	<.001	4	view →
CHOL	Male	All	+3.973	<.001	3	view →
READ	Male	All	+0.970	.032	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LINGO1–KIRC

Open the KIRC breakdown →