LINC02273

Across TCGA pan-cancer cohorts, LINC02273 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LINC02273’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02273 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02273 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where LINC02273 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02273 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.531	<.001	9	view →
HNSC	Female	IV	+0.678	.003	8	view →
LUSC	Male	II,III,IV	−0.492	<.001	5	view →
KICH	All	All	−0.268	.003	5	view →
STAD	All	All	+0.330	.007	4	view →
BRCA	All	All	+0.169	.016	4	view →
COAD	All	All	−0.161	.018	3	view →
THCA	All	All	−0.254	.037	1	view →
THCA	Male	IV	+0.149	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

LINC02273–KIRC

Open the KIRC breakdown →