LINC02270

Across TCGA pan-cancer cohorts, LINC02270 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC02270’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC02270 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02270 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

BRCA, PRAD, and HNSC are the cancer types where LINC02270 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02270 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.030	.011	4	view →
PRAD	All	All	−0.075	.001	2	view →
HNSC	All	IV	+0.027	.028	2	view →
KIRC	All	All	+0.008	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

LINC02270–BRCA

Open the BRCA breakdown →