long intergenic non-protein coding RNA 2270Genealiases: []
Q-omics provides the consensus-scored LINC02270 profile across patient tissues and cancer cell-line models. LINC02270 expression is associated with patient survival in 10 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, LINC02270 is differentially expressed in 4, with the highest sampling consensus in BRCA. Additionally, LINC02270 RNA expression shows 6,545 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LIHC, BRCA, and STAD as cancer lineages where LINC02270 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC02270 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC02270 survival associations across molecular data types. LINC02270 RNA expression shows survival associations in the most cancer types (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC02270 RNA expression–survival associations across cancer types. High LINC02270 expression shows unfavorable associations in LIHC, UVM, ACC, LUAD and PAAD, but favorable associations in BLCA. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify LIHC as the clearest survival context for LINC02270 RNA expression.
This table summarizes LINC02270 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for LINC02270. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC02270 shows lower tumor expression in PRAD and higher tumor expression in BRCA, HNSC and KIRC. The BRCA box plot shows higher LINC02270 RNA expression in tumor versus normal tissue (log2 FC = +0.030, t-test p = .011).
This table shows molecular features associated with LINC02270 in patient tissues and cancer cell lines. In patient samples, LINC02270 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
