LINC00858

Across TCGA pan-cancer cohorts, LINC00858 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LINC00858’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LINC00858 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00858 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where LINC00858 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00858 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.285	<.001	11	view →
LUAD	Male	All	+0.933	<.001	8	view →
STAD	Male	All	+0.788	<.001	8	view →
LUSC	Male	II,III,IV	+0.542	<.001	8	view →
HNSC	Male	II,III,IV	+0.218	<.001	8	view →
BLCA	All	All	+0.571	.001	7	view →
UCEC	All	III,IV	+1.351	<.001	6	view →
READ	All	All	+1.331	<.001	5	view →
KICH	Female	II,III,IV	−0.250	.018	4	view →
BRCA	All	All	+0.132	.001	4	view →
KIRC	Male	III,IV	−0.058	<.001	2	view →
LIHC	All	All	+0.035	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LINC00858–COAD

Open the COAD breakdown →