Q-omics provides the consensus-scored LINC00653 profile across patient tissues and cancer cell-line models. LINC00653 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LINC00653 is differentially expressed in 11, with the highest sampling consensus in LIHC. Additionally, LINC00653 RNA expression shows 18,291 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, LIHC, and UVM as cancer lineages where LINC00653 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00653 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00653 survival associations across molecular data types. LINC00653 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00653 RNA expression–survival associations across cancer types. High LINC00653 expression shows unfavorable associations in KIRC and LIHC, but favorable associations in UCS, BLCA, READ and SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LINC00653 RNA expression.
This table summarizes LINC00653 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in LIHC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00653. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00653 shows lower tumor expression in UCEC, LUAD, KICH and BRCA and higher tumor expression in LIHC and CHOL. The LIHC box plot shows higher LINC00653 RNA expression in tumor versus normal tissue (log2 FC = +0.308, t-test p < 0.001).
This table shows molecular features associated with LINC00653 in patient tissues and cancer cell lines. In patient samples, LINC00653 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
