LINC00653

Across TCGA pan-cancer cohorts, LINC00653 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC00653’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where LINC00653 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00653 is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.

LIHC, UCEC, and CHOL are the cancer types where LINC00653 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00653 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.308	<.001	8	view →
UCEC	All	All	−1.295	<.001	6	view →
CHOL	All	All	+1.963	<.001	5	view →
LUAD	All	III,IV	−0.556	<.001	5	view →
KICH	All	All	−0.701	<.001	4	view →
BRCA	Female	All	−0.477	<.001	4	view →
READ	All	II,III,IV	+0.314	.039	3	view →
BLCA	Male	IV	−0.767	.020	1	view →
THCA	Male	All	−0.391	.042	1	view →
HNSC	Female	All	+0.366	.044	1	view →
COAD	All	All	+0.226	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC00653–LIHC

Open the LIHC breakdown →