Q-omics provides the consensus-scored LINC00421 profile across patient tissues and cancer cell-line models. LINC00421 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in UVM. Additionally, LINC00421 RNA expression shows 6,616 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight UVM, and STAD as cancer lineages where LINC00421 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for LINC00421 — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes LINC00421 survival associations across molecular data types. LINC00421 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

LINC00421 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	14	UVM (95)	view →

This table ranks reproducible LINC00421 RNA expression–survival associations across cancer types. High LINC00421 expression shows unfavorable associations in UVM, STAD and KIRP, but favorable associations in UCS, BLCA and CESC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for LINC00421 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.422	0.758	<.001	95	view →
STAD	OS	Tertile	All	0.296	0.603	<.001	66	view →
KIRP	OS	Tertile	II,III,IV	0.135	0.707	.001	60	view →
UCS	DFS	Tertile	II,III,IV	0.651	0.142	<.001	48	view →
BLCA	DFS	Tertile	III,IV	0.732	0.154	.011	39	view →
CESC	OS	Tertile	All	1.000	0.774	.004	18	view →

Pink = unfavorable, green = favorable. all 14 lineages →

LINC00421-UVM (OS)

Kaplan–Meier survival curve for LINC00421 RNA expression in UVM: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with LINC00421 in patient tissues and cancer cell lines. In patient samples, LINC00421 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,616	STAD (5368)	view →
RNA	6,182	UVM (2015)	view →
▼Mutation
RNA	2	UCEC (2)	view →