Across TCGA pan-cancer cohorts, LINC00365 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC00365’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where LINC00365 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00365 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
LUAD, LUSC, and HNSC are the cancer types where LINC00365 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00365 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.