LINC-PINT

Across TCGA pan-cancer cohorts, LINC-PINT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LINC-PINT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LINC-PINT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC-PINT is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

COAD, LUSC, and THCA are the cancer types where LINC-PINT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC-PINT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+1.049	<.001	10	view →
LUSC	Female	II,III,IV	−1.415	<.001	8	view →
THCA	All	All	−0.396	<.001	8	view →
UCEC	All	All	−1.663	<.001	6	view →
BRCA	All	III,IV	−0.611	<.001	6	view →
LIHC	All	II,III,IV	+0.313	.009	3	view →
READ	All	II,III,IV	+1.040	.039	2	view →
KIRC	All	II,III,IV	−0.294	.020	2	view →
CHOL	All	All	+0.916	.012	1	view →
LUAD	Female	II,III,IV	−0.440	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LINC-PINT–COAD

Open the COAD breakdown →