LIMS4

Across TCGA cell cohorts, LIMS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,400 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LIMS4-associated GO terms across cancer lineages are Regulation of cellular response to transforming growth factor beta stimulus, Regulation of cell-matrix adhesion, and Negative regulation of protein modification process. Each is linked with LIMS4 in more than 8 cancer types. Because this analysis shows association rather than direction, both LIMS4-to-partner and partner-to-LIMS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cellular response to transforming growth factor beta stimulus grouped by LIMS4-low versus LIMS4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIMS4→partner) and Y-score (partner→LIMS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cellular response to transforming growth factor beta stimulus →	+0.069	+1.518	.001	.005	3	9
BONE	Regulation of cell-matrix adhesion →	+0.170	+1.123	<.001	<.001	3	9
LIVER	Negative regulation of protein modification process →	+0.039	+0.738	.009	.008	3	9
LIVER	Protein lipidation →	+0.127	+0.783	<.001	.004	3	8
UPPER_AERODIGESTIVE_TRACT	Response to oxygen levels →	+0.058	+0.673	<.001	<.001	3	8
BONE	Integrin-mediated signaling pathway →	+0.282	+1.160	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,400 associations by consensus.

Regulation of cellular response to transforming growth factor beta stimulus by LIMS4 expression — BONE

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