LIMS4

Across TCGA pan-cancer cohorts, LIMS4 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated LIMS4 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher LIMS4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LIMS4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

SKCM, KIRC, and STAD are the cancer types where LIMS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.350	0.792	<.001	120	view →
KIRC	DFS	Tertile	All	0.146	0.631	<.001	54	view →
STAD	DFS	Tertile	IV	0.121	0.432	.028	27	view →
PAAD	OS	Tertile	All	0.197	0.613	.016	27	view →
ACC	OS	Tertile	All	0.268	0.819	.016	18	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	18	view →
BLCA	DFS	Tertile	IV	0.156	0.478	.030	9	view →
SARC	DFS	Tertile	All	0.219	0.634	.025	9	view →
GBM	OS	Tertile	All	0.546	0.389	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

LIMS4–SKCM (OS)

Open the SKCM breakdown →