LIG3

Across TCGA patient cohorts, LIG3 protein abundance is significantly associated with the protein abundance of many other proteins, with 27,754 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIG3-associated proteins across cancer lineages are DHX9, EFTUD2, and RFC4. Each is linked with LIG3 in more than 9 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG3 versus DHX9 in LSCC, with a Pearson correlation of 0.82.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DHX9 →	+0.353	+0.682	<.001	<.001	3	10
LSCC	EFTUD2 →	+0.291	+0.638	<.001	<.001	3	10
LSCC	RFC4 →	+0.581	+0.571	<.001	<.001	3	10
GBM	SF3B1 →	+0.332	+0.560	<.001	<.001	3	10
GBM	SIN3A →	+0.362	+0.469	<.001	<.001	3	10
GBM	SNRNP200 →	+0.338	+0.517	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 27,754 associations by consensus.

LIG3 vs DHX9 — LSCC

Explore this scatter interactively →