LIF-AS1

Across TCGA pan-cancer cohorts, LIF-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LIF-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LIF-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LIF-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and STAD show a favorable association.

KIRC, KIRP, and THYM are the cancer types where LIF-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.512	0.731	<.001	167	view →
KIRP	DFS	Quartile	All	0.356	0.946	<.001	110	view →
THYM	DFS	Median	All	0.763	0.930	.001	52	view →
CESC	DFS	Median	III,IV	0.439	0.789	.003	52	view →
HNSC	OS	Tertile	III,IV	0.475	0.738	.001	40	view →
ACC	DFS	Quartile	All	0.291	0.704	.002	37	view →
MESO	OS	Median	II,III,IV	0.423	0.695	<.001	35	view →
READ	DFS	Median	III,IV	0.313	0.748	.007	27	view →
BRCA	OS	Quartile	IV	0.314	0.892	.010	25	view →
THCA	DFS	Tertile	IV	0.492	0.946	.001	20	view →
LGG	DFS	Tertile	All	0.705	0.851	.009	15	view →
ESCA	DFS	Tertile	IV	0.628	0.242	.024	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LIF-AS1–KIRC (DFS)

Open the KIRC breakdown →