LIF-AS1

Across TCGA pan-cancer cohorts, LIF-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LIF-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LIF-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types LIF-AS1 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

LUSC, KIRC, and STAD are the cancer types where LIF-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIF-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−0.279	<.001	7	view →
KIRC	All	All	+0.143	<.001	5	view →
STAD	All	All	+0.168	.004	4	view →
UCEC	All	II,III,IV	−0.272	.034	2	view →
COAD	All	All	+0.180	.005	2	view →
KICH	Female	All	−0.083	.022	2	view →
HNSC	Male	III,IV	+0.062	.025	2	view →
CHOL	All	All	+0.114	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

LIF-AS1–LUSC

Open the LUSC breakdown →