LHFPL2

Across TCGA patient cohorts, LHFPL2 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL2-associated genes across cancer lineages are PABPC1L2B-AS1, LINC00653, and FCGBP. Each is linked with LHFPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHFPL2-to-partner and partner-to-LHFPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2B-AS1 grouped by LHFPL2-low versus LHFPL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL2→partner) and Y-score (partner→LHFPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PABPC1L2B-AS1 →	+0.039	+7.816	<.001	.008	3	3
UCEC	LINC00653 →	-0.535	-3.584	.002	.002	3	1
UCEC	FCGBP →	-1.205	-3.443	.002	.005	3	1
UCEC	UHRF1 →	+0.788	+2.818	.005	.001	3	1
UCEC	SLC25A4 →	+0.654	+3.724	<.001	<.001	3	1
UCEC	AP1S3 →	+0.652	+2.860	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

PABPC1L2B-AS1 by LHFPL2 expression — SKCM

Explore this box plot interactively →