LGMN

Across TCGA patient cohorts, LGMN mutation is significantly associated with the RNA expression of many other genes, with 1,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGMN-associated genes across cancer lineages are SLC3A2, UPP1, and LONP1. Each is linked with LGMN in more than 1 cancer types. Because this analysis shows association rather than direction, both LGMN-to-partner and partner-to-LGMN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC3A2 grouped by LGMN-low versus LGMN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGMN→partner) and Y-score (partner→LGMN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC3A2 →	+0.619	+3.195	.002	.009	3	2
SKCM	UPP1 →	+0.938	+3.182	.002	.009	3	2
UCEC	LONP1 →	+0.696	+3.064	<.001	<.001	3	2
SKCM	FLVCR1-DT →	+0.521	+2.826	.009	.001	3	2
SKCM	ANXA2P1 →	+0.332	+2.516	.001	.009	3	2
SKCM	LINC01705 →	+1.529	+3.331	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,177 associations by consensus.

SLC3A2 by LGMN expression — SKCM

Explore this box plot interactively →