LGMN

Across TCGA pan-cancer cohorts, LGMN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LGMN’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LGMN RNA is repressed in tumor relative to normal tissue. In most cancer types LGMN is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, HNSC, and STAD are the cancer types where LGMN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGMN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.844	<.001	10	view →
HNSC	Female	II,III,IV	+1.134	<.001	10	view →
STAD	Male	III,IV	+1.028	<.001	6	view →
LUSC	Male	All	−0.504	<.001	6	view →
KICH	Female	All	+1.264	<.001	5	view →
UCEC	All	II,III,IV	+0.802	.024	4	view →
BRCA	All	II,III,IV	−0.415	<.001	4	view →
LIHC	All	II,III,IV	+0.599	.005	3	view →
ESCA	All	All	+1.021	.005	2	view →
PRAD	All	All	+0.291	.040	2	view →
CHOL	All	All	+0.903	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LGMN–THCA

Open the THCA breakdown →