LGI1

Across TCGA patient cohorts, LGI1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,167 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI1-associated proteins across cancer lineages are KANK2, SYNPO2_S781, and PPP1R12B. Each is linked with LGI1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LGI1-to-partner and partner-to-LGI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI1 versus KANK2 in COAD, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI1→partner) and Y-score (partner→LGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KANK2 →	+0.528	+0.090	<.001	<.001	3	5
CCRCC	SYNPO2_S781 →	+0.954	+0.033	<.001	.003	3	5
COAD	PPP1R12B →	+0.745	+0.090	<.001	<.001	3	4
COAD	PRKG1 →	+0.671	+0.143	<.001	<.001	3	4
GBM	PYGM →	+1.058	+1.071	<.001	<.001	3	4
HNSC	THBS4 →	+1.571	+0.187	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,167 associations by consensus.

LGI1 vs KANK2 — COAD

Explore this scatter interactively →