LGI1

Across TCGA pan-cancer cohorts, LGI1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LGI1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LGI1 RNA is repressed in tumor relative to normal tissue. In most cancer types LGI1 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and HNSC are the cancer types where LGI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.940	<.001	11	view →
BLCA	Male	All	−0.527	<.001	11	view →
HNSC	All	All	−0.184	<.001	10	view →
THCA	Male	II,III,IV	−0.148	<.001	10	view →
STAD	Female	All	−0.740	<.001	8	view →
READ	All	III,IV	−1.375	<.001	7	view →
UCEC	All	All	−0.136	<.001	6	view →
LIHC	Female	All	−0.232	<.001	5	view →
KIRP	Female	II,III,IV	−0.028	.005	4	view →
LUAD	All	II,III,IV	−0.021	.014	3	view →
ESCA	All	All	−0.412	.023	2	view →
CHOL	Female	All	−0.486	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LGI1–COAD

Open the COAD breakdown →