LGI1

Across TCGA patient cohorts, LGI1 mutation is significantly associated with the RNA expression of many other genes, with 3,294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGI1-associated genes across cancer lineages are MEX3D, ARRDC1-AS1, and RNY4P27. Each is linked with LGI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGI1-to-partner and partner-to-LGI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEX3D grouped by LGI1-low versus LGI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI1→partner) and Y-score (partner→LGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEX3D →	+0.704	+3.928	<.001	<.001	3	3
UCEC	ARRDC1-AS1 →	+0.546	+3.403	<.001	<.001	3	3
LGG	RNY4P27 →	+0.337	+6.646	<.001	<.001	3	3
UCEC	HROB →	+0.683	+3.711	<.001	<.001	3	3
UCEC	DGCR6L →	+0.481	+3.470	<.001	.002	3	3
UCEC	SPATA5 →	+0.496	+2.923	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,294 associations by consensus.

MEX3D by LGI1 expression — UCEC

Explore this box plot interactively →