LGALS8

Across TCGA patient cohorts, LGALS8 mutation is significantly associated with the RNA expression of many other genes, with 2,826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS8-associated genes across cancer lineages are RN7SL248P, MIR1261, and UBL5P1. Each is linked with LGALS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS8-to-partner and partner-to-LGALS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by LGALS8-low versus LGALS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS8→partner) and Y-score (partner→LGALS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.007	3	2
CESC	MIR1261 →	+0.445	+7.174	<.001	<.001	3	2
COAD	UBL5P1 →	+0.390	+5.283	<.001	.006	3	2
SKCM	RNA5SP451 →	+0.312	+6.485	<.001	<.001	3	2
UCEC	ETF1P3 →	+0.115	+1.731	.002	.004	3	2
UCEC	DCP1A →	+0.455	+2.724	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,826 associations by consensus.

RN7SL248P by LGALS8 expression — UCEC

Explore this box plot interactively →