LGALS8

Across TCGA pan-cancer cohorts, LGALS8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LGALS8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LGALS8 RNA is repressed in tumor relative to normal tissue. In most cancer types LGALS8 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where LGALS8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGALS8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.237	<.001	10	view →
HNSC	All	III,IV	+0.678	<.001	10	view →
LIHC	Female	II,III,IV	+1.297	<.001	9	view →
KIRC	Female	All	+0.527	<.001	9	view →
BRCA	All	III,IV	+0.741	<.001	6	view →
STAD	All	II,III,IV	+0.682	<.001	6	view →
BLCA	All	All	+0.468	.005	6	view →
ESCA	All	II,III,IV	+0.724	.014	3	view →
CHOL	Male	All	+1.369	<.001	2	view →
LUAD	All	III,IV	−0.323	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LGALS8–KICH

Open the KICH breakdown →