LGALS12

Across TCGA cell cohorts, LGALS12 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LGALS12-associated genes across cancer lineages are MMP26, MAS1L, and TBC1D3. Each is linked with LGALS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS12-to-partner and partner-to-LGALS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by LGALS12-low versus LGALS12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS12→partner) and Y-score (partner→LGALS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.016	+4.437	<.001	.004	3	1
SKIN	MAS1L →	+0.098	+4.054	<.001	.004	3	1
SKIN	TBC1D3 →	+0.931	+4.882	<.001	<.001	3	1
LUNG_SCLC	TAS2R60 →	+1.253	+5.643	<.001	.002	3	1
LARGE_INTESTINE	TNP1 →	+0.128	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MMP26 by LGALS12 expression — SKIN

Explore this box plot interactively →