LGALS12

Across TCGA pan-cancer cohorts, LGALS12 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LGALS12 data layer compared with 2 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher LGALS12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LGALS12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

OV, STAD, and LGG are the cancer types where LGALS12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	III,IV	0.759	0.906	.001	36	view →
STAD	OS	Tertile	All	0.613	0.756	.002	35	view →
LGG	DFS	Tertile	All	0.639	0.785	<.001	34	view →
HNSC	DFS	Quartile	All	0.427	0.248	.002	32	view →
ESCA	DFS	Tertile	All	0.450	0.220	.004	31	view →
UCS	OS	Quartile	III,IV	0.252	0.633	.007	30	view →
CHOL	DFS	Median	All	0.650	0.159	<.001	25	view →
UVM	DFS	Quartile	III,IV	0.992	0.402	.013	18	view →
KIRC	DFS	Tertile	All	0.554	0.713	.005	16	view →
LUAD	OS	Median	All	0.884	0.781	.005	16	view →
COAD	DFS	Tertile	III,IV	0.741	0.522	.015	14	view →
BRCA	OS	Tertile	III,IV	0.694	0.493	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LGALS12–OV (OS)

Open the OV breakdown →