LDHC

Across TCGA patient cohorts, LDHC mutation is significantly associated with the RNA expression of many other genes, with 1,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHC-associated genes across cancer lineages are MIR6070, RNA5SP321, and MIR6871. Each is linked with LDHC in more than 2 cancer types. Because this analysis shows association rather than direction, both LDHC-to-partner and partner-to-LDHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6070 grouped by LDHC-low versus LDHC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHC→partner) and Y-score (partner→LDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6070 →	+0.183	+3.010	.001	.003	3	3
HNSC	RNA5SP321 →	+0.286	+5.435	.002	.005	3	2
SKCM	MIR6871 →	+0.581	+2.295	<.001	.009	3	2
BLCA	MIR5591 →	+0.420	+7.640	<.001	.009	3	2
COAD	PHBP6 →	+0.076	+5.332	<.001	.002	3	2
LUAD	SNX18P8 →	+0.049	+4.502	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,207 associations by consensus.

MIR6070 by LDHC expression — SKCM

Explore this box plot interactively →