LDHC

Across TCGA pan-cancer cohorts, LDHC RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LDHC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where LDHC RNA is repressed in tumor relative to normal tissue. In most cancer types LDHC is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and KIRC are the cancer types where LDHC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LDHC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−0.865	<.001	11	view →
KICH	Female	All	−0.363	.001	7	view →
KIRC	All	All	−0.506	<.001	5	view →
LUSC	All	All	+0.362	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

LDHC–KIRP

Open the KIRP breakdown →