LDHAL6B

Across TCGA patient cohorts, LDHAL6B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHAL6B-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and A-Raf_pS299. Each is linked with LDHAL6B in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHAL6B-to-partner and partner-to-LDHAL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by LDHAL6B-low versus LDHAL6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHAL6B→partner) and Y-score (partner→LDHAL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.662	+2.604	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.502	.005	.002	3	1
UCEC	A-Raf_pS299 →	-0.193	-3.700	<.001	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.157	-1.571	.017	.036	3	1
UCEC	Ku80 →	+0.264	+2.009	.004	.017	3	1
UCEC	MAPK_pT202_Y204 →	-0.422	-3.308	.022	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Annexin-1 by LDHAL6B expression — UCEC

Explore this box plot interactively →