LDHAL6B

Across TCGA pan-cancer cohorts, LDHAL6B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LDHAL6B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LDHAL6B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LDHAL6B is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where LDHAL6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LDHAL6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.108	<.001	8	view →
COAD	All	II,III,IV	−0.177	.001	7	view →
KICH	All	All	−0.172	<.001	6	view →
STAD	All	II,III,IV	+0.325	.003	4	view →
READ	Male	All	−0.326	.011	2	view →
BRCA	All	III,IV	−0.167	.001	2	view →
UCEC	All	All	−0.136	.029	2	view →
THCA	Female	All	−0.090	.006	2	view →
CHOL	All	All	+0.257	.032	1	view →
LUAD	All	All	+0.193	.037	1	view →
KIRP	Male	All	−0.110	.030	1	view →
LIHC	Female	III,IV	−0.056	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LDHAL6B–HNSC

Open the HNSC breakdown →