LDHAL6B

Across TCGA pan-cancer cohorts, LDHAL6B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LDHAL6B data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LDHAL6B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LDHAL6B expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

ACC, LGG, and SCLC are the cancer types where LDHAL6B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.277	0.759	<.001	66	view →
LGG	OS	Tertile	All	0.373	0.558	<.001	34	view →
SCLC	DFS	Median	All	0.671	0.450	.010	31	view →
KIRC	DFS	Tertile	All	0.584	0.748	.004	31	view →
MESO	OS	Quartile	III,IV	0.355	0.595	.015	27	view →
LUSC	OS	Median	IV	0.255	0.851	.021	21	view →
CESC	DFS	Median	III,IV	0.151	0.576	.002	18	view →
PAAD	DFS	Tertile	All	0.194	0.412	.005	13	view →
UCS	DFS	Tertile	IV	0.860	0.364	.024	12	view →
READ	DFS	Quartile	IV	0.222	0.725	.003	12	view →
LUAD	OS	Tertile	All	0.766	0.843	.010	12	view →
UCEC	OS	Tertile	All	0.910	0.957	.034	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LDHAL6B–ACC (OS)

Open the ACC breakdown →