LDHA

Across TCGA patient cohorts, LDHA RNA expression is significantly associated with the protein abundance of many other proteins, with 16,728 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LDHA-associated proteins across cancer lineages are TPI1_S80, P4HA1, and PLOD2. Each is linked with LDHA in more than 8 cancer types. Because this analysis shows association rather than direction, both LDHA-to-partner and partner-to-LDHA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDHA versus TPI1_S80 in LSCC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHA→partner) and Y-score (partner→LDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TPI1_S80 →	+0.637	+0.802	<.001	<.001	3	9
GBM	P4HA1 →	+0.824	+1.039	<.001	<.001	3	8
OV	PLOD2 →	+1.043	+0.831	<.001	<.001	3	8
BRCA	ERO1A →	+0.754	+0.740	<.001	<.001	3	7
GBM	HK2 →	+0.625	+0.832	<.001	<.001	3	7
UCEC	HMGN4 →	-0.653	-0.848	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,728 associations by consensus.

LDHA vs TPI1_S80 — LSCC

Explore this scatter interactively →