LDHA

Across TCGA patient cohorts, LDHA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHA-associated genes across cancer lineages are A-Raf_pS299, ERK2, and INPP4B. Each is linked with LDHA in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHA-to-partner and partner-to-LDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by LDHA-low versus LDHA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHA→partner) and Y-score (partner→LDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.108	-3.000	.025	.036	3	1
UCEC	ERK2 →	+0.221	+3.584	.004	.002	3	1
UCEC	INPP4B →	-0.283	-3.321	.029	.009	3	1
UCEC	JNK2 →	+0.210	+3.026	.008	.018	3	1
UCEC	p27_pT198 →	+0.108	+2.415	.012	.003	3	1
UCEC	p62 Lck ligand →	+0.332	+2.009	.011	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by LDHA expression — UCEC

Explore this box plot interactively →