LDB2

Across TCGA patient cohorts, LDB2 mutation is significantly associated with the RNA expression of many other genes, with 3,784 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDB2-associated genes across cancer lineages are RCC1, TRAIP, and FAM162B. Each is linked with LDB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LDB2-to-partner and partner-to-LDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by LDB2-low versus LDB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB2→partner) and Y-score (partner→LDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC1 →	+0.399	+1.903	.003	<.001	3	3
UCEC	TRAIP →	+0.438	+2.906	.003	.001	3	3
UCEC	FAM162B →	-0.498	-2.563	.001	<.001	3	3
UCEC	CRYBB2P1 →	+0.447	+2.879	<.001	<.001	3	3
UCEC	HIRA →	+0.397	+3.939	<.001	<.001	3	3
UCEC	TLE6 →	+0.625	+1.914	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,784 associations by consensus.

RCC1 by LDB2 expression — UCEC

Explore this box plot interactively →