LCT

Across TCGA cell cohorts, LCT mutation is significantly associated with the RNA expression of many other genes, with 731 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCT-associated genes across cancer lineages are MAJIN, TBC1D3, and MAPK8. Each is linked with LCT in more than 2 cancer types. Because this analysis shows association rather than direction, both LCT-to-partner and partner-to-LCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAJIN grouped by LCT-low versus LCT-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCT→partner) and Y-score (partner→LCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAJIN →	+0.140	+3.000	.004	.007	3	3
LUNG_NSCLC_LUSC	TBC1D3 →	+0.470	+4.108	.005	.005	3	2
LARGE_INTESTINE	MAPK8 →	+0.567	+3.169	.005	.006	2	3
SKIN	NTMT1 →	+0.476	+3.257	.003	.002	3	2
BLOOD_Leukemia	SMIM43 →	+0.812	+3.930	<.001	.003	3	2
BLOOD_Leukemia	FAM160A1 →	+0.272	+3.684	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

MAJIN by LCT expression — CNS

Explore this box plot interactively →