LCT

Across TCGA pan-cancer cohorts, LCT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LCT’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LCT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCT is over-expressed in tumor, although a few such as STAD and KICH show the opposite, repressed pattern.

BLCA, LUAD, and LIHC are the cancer types where LCT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+0.035	.019	5	view →
LUAD	All	All	+0.254	<.001	4	view →
LIHC	All	All	+0.013	.002	3	view →
STAD	Male	All	−1.013	.033	2	view →
UCEC	All	IV	+0.270	.046	2	view →
LUSC	All	All	+0.183	.008	2	view →
PRAD	All	All	+0.018	.004	2	view →
CHOL	All	All	+0.033	.031	1	view →
KICH	Female	All	−0.012	.019	1	view →
KIRC	Male	All	+0.007	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LCT–BLCA

Open the BLCA breakdown →