LCORL

Across TCGA cell cohorts, LCORL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LCORL-associated genes across cancer lineages are CRISP1, DAZ4, and CST11. Each is linked with LCORL in more than 1 cancer types. Because this analysis shows association rather than direction, both LCORL-to-partner and partner-to-LCORL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP1 grouped by LCORL-low versus LCORL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCORL→partner) and Y-score (partner→LCORL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRISP1 →	+0.019	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DAZ4 →	+0.326	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	CST11 →	+1.002	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	OR10A5 →	+0.028	+4.070	<.001	.004	3	1
BLOOD_Lymphoma	SPATA8 →	+0.136	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.032	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CRISP1 by LCORL expression — LARGE_INTESTINE

Explore this box plot interactively →