LCORL

Across TCGA pan-cancer cohorts, LCORL RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LCORL’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where LCORL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCORL is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

STAD, LIHC, and THCA are the cancer types where LCORL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCORL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.722	<.001	8	view →
LIHC	Male	All	+0.549	<.001	8	view →
THCA	All	All	−0.299	<.001	6	view →
HNSC	All	III,IV	+0.356	.005	5	view →
BRCA	All	II,III,IV	+0.374	<.001	4	view →
CHOL	Male	All	+1.744	<.001	3	view →
LUAD	Male	All	+0.394	.009	2	view →
PRAD	All	All	+0.342	<.001	2	view →
LUSC	All	III,IV	−0.353	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LCORL–STAD

Open the STAD breakdown →