LCE3D

Across TCGA patient cohorts, LCE3D mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE3D-associated genes across cancer lineages are MEK1_p_S217_S221, PCNA, and CD20. Each is linked with LCE3D in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE3D-to-partner and partner-to-LCE3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by LCE3D-low versus LCE3D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE3D→partner) and Y-score (partner→LCE3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEK1_p_S217_S221 →	+0.300	+2.182	.007	.033	3	2
UCEC	PCNA →	+0.362	+3.169	.002	.020	3	1
UCEC	CD20 →	+0.190	+3.169	.008	.020	3	1
SKCM	JNK2 →	-0.323	-2.442	<.001	.020	3	1
UCEC	Chk2 →	-0.391	-3.169	.002	.019	2	1
UCEC	p27_pT198 →	+0.208	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1_p_S217_S221 by LCE3D expression — SKCM

Explore this box plot interactively →