LCE3D

Across TCGA pan-cancer cohorts, LCE3D RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LCE3D data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher LCE3D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LCE3D expression acts as an unfavorable survival marker, although some lineages such as ESCA and LIHC show a favorable association.

BLCA, KIRP, and KICH are the cancer types where LCE3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.325	0.485	<.001	153	view →
KIRP	OS	Tertile	II,III,IV	0.434	0.880	<.001	96	view →
KICH	DFS	Tertile	II,III,IV	0.043	0.883	<.001	87	view →
ESCA	OS	Tertile	IV	0.743	0.290	.013	72	view →
THCA	DFS	Tertile	II,III,IV	0.114	0.738	<.001	66	view →
KIRC	OS	Tertile	All	0.414	0.645	.004	54	view →
COAD	OS	Tertile	IV	0.102	0.695	<.001	51	view →
LUAD	OS	Tertile	All	0.466	0.693	.005	36	view →
SKCM	OS	Quartile	All	0.669	0.813	<.001	33	view →
ACC	OS	Tertile	All	0.698	0.891	.005	30	view →
READ	DFS	Tertile	All	0.515	0.804	.023	30	view →
SARC	DFS	Tertile	All	0.353	0.545	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LCE3D–BLCA (OS)

Open the BLCA breakdown →