LCE3C

Across TCGA cell cohorts, LCE3C RNA expression is significantly associated with the mutation status of many other genes, with 6 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible LCE3C-associated genes across cancer lineages are TRIOBP, ERF, and RSPO3. Each is linked with LCE3C in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE3C-to-partner and partner-to-LCE3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIOBP grouped by LCE3C-low versus LCE3C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE3C→partner) and Y-score (partner→LCE3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TRIOBP →	+3.736	+0.966	.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	ERF →	+4.736	+1.897	.009	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	RSPO3 →	+4.736	+1.908	.009	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	CHMP6 →	+4.736	+1.897	.009	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	TRAK1 →	+4.321	+1.160	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CEP290 →	+4.736	+1.908	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TRIOBP by LCE3C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →